Is Dyphylline safe in cosmetics?
Dyphylline has a safety rating of "POOR" in our database. EU status: permitted. US status: restricted.
Poor
Cosmetic Ingredient
Dyphylline
Also known as: 5-26-14-00070, BRN 0284563, Dihydroxypropyl theophylline, 7-(2,3-Dioxypropyl)theophylline, Diprofilline (+15 more)
INCI: DYPHYLLINE
Dyphylline (CAS 479-18-5) is a cosmetic cosmetic ingredient functioning as Phosphodiesterase inhibitor and adenosine receptor antagonist with primary. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 479-18-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dyphylline is classified GHS Danger (H302, H370, H372, H332) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Phosphodiesterase inhibitor and adenosine receptor antagonist with primary pharmaceutical use as a bronchodilator; not a standard cosmetic function
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione
InChIKey
KSCFJBIXMNOVSH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Recognized as a drug under 21 CFR and listed as a bronchodilator. Cosmetic use would likely trigger drug/cosmetic dual classification under the FD&C Act.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dyphylline.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Dyphylline.
Known Synonyms
5-26-14-00070
BRN 0284563
Dihydroxypropyl theophylline
7-(2,3-Dioxypropyl)theophylline
Diprofilline
Dipropylline
Droxine
EINECS 207-526-1
Glyphyllinum
Liactemin
1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl
Diprofillina
Diprophyllinum
UNII-263T0E9RR9
(+-)-7-(2,3-dihydroxypropyl)theophylline
(+-)-diprophylline
(+-)-dyphylline
(1,2-dihydroxy-3-propyl)thiophyllin
1,3-dimethyl-7-(2,3-dihydroxypropyl)xanthine
7-(2,3-dihydroxypropyl)-1,3-dimethylxanthine
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DYPHYLLINE
ChEMBL ID
CHEMBL1752
Max Phase
4
Adverse Event Associations
35
Frequently Asked Questions
Is Dyphylline allowed in the EU?
Dyphylline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dyphylline do in cosmetics?
Dyphylline functions as: Phosphodiesterase inhibitor and adenosine receptor antagonist with primary pharmaceutical use as a bronchodilator; not a standard cosmetic function. It is classified as a cosmetic ingredient in our database. CAS number: 479-18-5.
Is Dyphylline used outside cosmetics?
Dyphylline also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dyphylline have different safety status in cosmetics vs industrial chemicals?
Dyphylline is classified GHS Danger (H302, H370, H372, H332) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dyphylline compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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