Is Ethosomes safe in cosmetics?
Ethosomes has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Ethosomes
INCI: ETHOSOMES
Ethosomes is a cosmetic cosmetic ingredient functioning as Delivery system; phospholipid vesicles with ethanol. EU Regulation 1223/2009 status: permitted.
Auto-generated CPSR Part A draft with source citations
Function
Delivery system; phospholipid vesicles with ethanol
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA-specific approval for ethosomes as delivery system. Components (lecithin, ethanol) permitted. Under MoCRA, safety substantiation must account for 5-87x enhanced dermal absorption. Marketed products (Noicellex, Cellulight EF, Decorin Cream) exist; no FDA enforcement actions identified.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethosomes.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
encapsulation
{"system_id": "ENC0130", "cas_number": "mix", "ingredient_class": "ethosome", "wall_material_type": "phospholipid", "wall_material_composition": "PC:ethanol_30-45%", "core_material_compatibility": "amphiphilic", "particle_size_range_nm": "100-400", "PDI_typical": "0.20-0.45", "zeta_potential_mV_typical": "-22 to -40", "encapsulation_efficiency_pct_typical": "65-92", "loading_capacity_pct_typical":…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Ethosomes.
Regulatory Flags
enhanced-dermal-penetration
nanovesicular-delivery
ethanol-20-45pct
no-sccs-opinion
no-cir-system-review
sensitization-amplification-risk
mos-recalculation-required
Frequently Asked Questions
Is Ethosomes allowed in the EU?
Ethosomes EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethosomes do in cosmetics?
Ethosomes functions as: Delivery system; phospholipid vesicles with ethanol. It is classified as a cosmetic ingredient in our database.
Compliance Tools
Check Ethosomes compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
ETHOXY-METHOXYMETHYL-PHENOL
Good
Browse nearby
Perfuming
ETHOXYDIGLYCOL ACETATE
Good
Browse nearby
Solvent
ETHOXYHEPTYL BICYCLOOCTANONE
Good
Browse nearby
Skin Conditioning
Is Ethosomes in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ethosomes in your formulation.