Ethyl 3-Hydroxybutyrate

INCI: ETHYL 3-HYDROXYBUTYRATE

CAS Number
5405-41-4
Function
Fragrance (perfuming agent); also flavoring (FEMA GRAS)
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” FEMA GRAS; no specific CFR restriction for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Endogenous metabolite with long history of safe use. One of the lowest-risk fragrance materials.

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Concern Level: None

Regulatory Flags

fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Ethyl 3-Hydroxybutyrate safe in cosmetics?

Endogenous metabolite with long history of safe use. One of the lowest-risk fragrance materials. The EU classifies Ethyl 3-Hydroxybutyrate as "permitted". Safety rating: EXCELLENT.

Is Ethyl 3-Hydroxybutyrate allowed in the EU?

Ethyl 3-Hydroxybutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl 3-Hydroxybutyrate do in cosmetics?

Ethyl 3-Hydroxybutyrate functions as: Fragrance (perfuming agent); also flavoring (FEMA GRAS). It is classified as a cosmetic ingredient in our database. CAS number: 5405-41-4.

What is the Margin of Safety for Ethyl 3-Hydroxybutyrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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