Moderate Cosmetic Ingredient Sensitization Data

Ethyl Cinnamate

CAS Number
103-36-6 [^1_10]
Function
Flavouring and nutrient; Fragrance; No specific technical function; UV stabilizer
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no 21 CFR restriction for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Ethyl Cinnamate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
balsam-of-peru-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS/1459/11

Expert Verdict

Structural alert for sensitization as a cinnamic acid ester; monitor SCCS extended allergen list updates; recommend HRIPT if used above 0.1% in leave-on products

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Ethyl Cinnamate safe in cosmetics?

Structural alert for sensitization as a cinnamic acid ester; monitor SCCS extended allergen list updates; recommend HRIPT if used above 0.1% in leave-on products The EU classifies Ethyl Cinnamate as "restricted". Safety rating: MODERATE.

Is Ethyl Cinnamate allowed in the EU?

Ethyl Cinnamate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Cinnamate do in cosmetics?

Ethyl Cinnamate functions as: Flavouring and nutrient; Fragrance; No specific technical function; UV stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 103-36-6 [^1_10].

What is the Margin of Safety for Ethyl Cinnamate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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