Is Ethyl Linoleate safe in cosmetics?
Ethyl Linoleate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Emollient
Ethyl Linoleate
Also known as: EINECS 208-868-4, Linoleic acid ethyl ester, NSC 50447, UNII-MJ2YTT4J8M
INCI: ETHYL LINOLEATE
Ethyl Linoleate (CAS 544-35-4) is a cosmetic emollient functioning as Emollient, Skin Conditioning, Skin-Brightening Agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 544-35-4 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, Skin Conditioning, Skin-Brightening Agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
ethyl (9Z,12Z)-octadeca-9,12-dienoate
InChIKey
FMMOOAYVCKXGMF-MURFETPASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Linoleate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
depigmentation
{"cas_number": "544-35-4", "ingredient_class": "melanosome_transfer_inhibitor", "primary_mechanism_of_action": "Linoleic acid ester inhibits melanosome transfer to keratinocytes", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_c…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "10-11", "co_emulsifier_pairs": "polysorbate_80,oleth_10", "optimal_oil_phase_pct": "10-30", "optimal_water_phase_pct": "70-90", "droplet_size_range_um": "1-20", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "poor", "rheology_modifier_type": "newt…
sensory
{"silky": "light", "smooth, glides easily": "light, spreads easily", "dry-touch, non-greasy": "dry, non-greasy", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "no", "1.40": "1.47", "transparent": "transparent", "colorless": "colorless", "excellent": "excellent", "light": "light", "synthetic": "botanical"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Linoleate.
Regulatory Flags
ifra_fragrance
Known Synonyms
EINECS 208-868-4
Linoleic acid ethyl ester
NSC 50447
UNII-MJ2YTT4J8M
Chemical Function
Softener and conditioner
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
Cleaning products and household care - air freshener; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ETHYL LINOLEATE
ChEMBL ID
CHEMBL2106238
Max Phase
1
Frequently Asked Questions
Is Ethyl Linoleate allowed in the EU?
Ethyl Linoleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Linoleate do in cosmetics?
Ethyl Linoleate functions as: Emollient, Skin Conditioning, Skin-Brightening Agent. It is classified as a Emollient in our database. CAS number: 544-35-4.
Is Ethyl Linoleate used outside cosmetics?
Ethyl Linoleate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Linoleate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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