Is Dibutyl Sulphide safe in cosmetics?
Dibutyl Sulphide has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Dibutyl Sulphide
Also known as: 4-01-00-01559, BRN 1732829, n-Butyl-sulfide, Di-n-butylsulfide, EINECS 208-870-5 (+3 more)
INCI: DIBUTYL SULPHIDE
Dibutyl Sulphide (CAS 544-40-1) is a cosmetic cosmetic ingredient functioning as Masking agent (limited cosmetic relevance); primarily an industrial/laboratory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 544-40-1 →
Auto-generated CPSR Part A draft with source citations
Function
Masking agent (limited cosmetic relevance); primarily an industrial/laboratory chemical
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1-butylsulfanylbutane
InChIKey
HTIRHQRTDBPHNZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not a recognized cosmetic ingredient; no CFR cosmetic listing
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibutyl Sulphide.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
581 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [362] Kligman AM (1975): Report to RIFM, 19 May, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
| HRIPT | - | 0 | 581 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
455
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,1'-THIOBISBUTANE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYLTHIOBUTANE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL SULFIDE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dibutyl Sulphide.
Regulatory Flags
ifra_fragrance
fda_food_additive
Known Synonyms
4-01-00-01559
BRN 1732829
n-Butyl-sulfide
Di-n-butylsulfide
EINECS 208-870-5
FEMA No. 2215
1,1'-Thiobis(butane)
UNII-3E3H471GA3
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561568
Frequently Asked Questions
Is Dibutyl Sulphide allowed in the EU?
Dibutyl Sulphide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Sulphide do in cosmetics?
Dibutyl Sulphide functions as: Masking agent (limited cosmetic relevance); primarily an industrial/laboratory chemical. It is classified as a cosmetic ingredient in our database. CAS number: 544-40-1.
Is Dibutyl Sulphide used outside cosmetics?
Dibutyl Sulphide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dibutyl Sulphide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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