Is Ethyl Pyrrolidone safe in cosmetics?
Ethyl Pyrrolidone has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Ethyl Pyrrolidone
Also known as: 2-Pyrrolidinone, 1-ethyl-, 5-21-06-00328, BRN 0107971, EINECS 220-250-6, N-Ethylpyrrolidinone (+2 more)
INCI: ETHYL PYRROLIDONE
Ethyl Pyrrolidone (CAS 2687-91-4) is a cosmetic cosmetic ingredient functioning as Solvent. CosIng lists it without a specific cosmetic function assignment, but. Reported NOAEL =250 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2687-91-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethyl Pyrrolidone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H360, H361, H360D).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent. CosIng lists it without a specific cosmetic function assignment, but chemically it is used as a high-performance solvent.
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-ethylpyrrolidin-2-one
InChIKey
ZFPGARUNNKGOBB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not specifically prohibited. EPA has proposed a Significant New Use Rule (SNUR) for industrial applications, indicating regulatory attention.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Pyrrolidone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Ethyl Pyrrolidone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Repr. 1B
Hazard Statements
- H360D
Inserted via ATP: ATP05
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1562
(EU) 2019/831
CMR: Reprotoxic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1562
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Pyrrolidone.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Pyrrolidone by CAS number or substance name.
Studies
1
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Pyrrolidinone, 1-ethyl-
5-21-06-00328
BRN 0107971
EINECS 220-250-6
N-Ethylpyrrolidinone
N-Ethylpyrrolidone
UNII-H0229SX1CW
Chemical Function
Solvent
Regulatory Lists
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL12221
Frequently Asked Questions
Is Ethyl Pyrrolidone allowed in the EU?
Ethyl Pyrrolidone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Pyrrolidone do in cosmetics?
Ethyl Pyrrolidone functions as: Solvent. CosIng lists it without a specific cosmetic function assignment, but chemically it is used as a high-performance solvent.. It is classified as a cosmetic ingredient in our database. CAS number: 2687-91-4.
What is the NOAEL for Ethyl Pyrrolidone?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Pyrrolidone is =250 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Ethyl Pyrrolidone used outside cosmetics?
Ethyl Pyrrolidone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethyl Pyrrolidone have different safety status in cosmetics vs industrial chemicals?
Ethyl Pyrrolidone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H360, H361, H360D).
Compliance Tools
Check Ethyl Pyrrolidone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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