Also known as: 2-Pyrrolidinone, 1-ethyl-, 5-21-06-00328, BRN 0107971, EINECS 220-250-6, N-Ethylpyrrolidinone (+2 more)
INCI: ETHYL PYRROLIDONE
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) (CAS 2687-91-4) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =250 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H360, H361, H360D).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP).
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg bw/day | oral | Rat | short-term | ECHA |
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: ATP05
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Preliminary editorial summary for Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 2687-91-4.
The NOAEL (No Observed Adverse Effect Level) for Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) is =250 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ECHA.
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H360, H361, H360D).
Check Ethyl Pyrrolidone (1-Ethyl-2-Pyrrolidone / NEP) compliance across multiple jurisdictions:
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