Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Ethyl Trisiloxane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Low acute oral, dermal, and inhalation toxicity per rat studies. Used in mascara, lipstick, foundations, lotions, creams, and hairspray at 1-20%. Australian NICNAS full public report available confirming safety.
Frequently Asked Questions
Is Ethyl Trisiloxane safe in cosmetics?
Low acute oral, dermal, and inhalation toxicity per rat studies. Used in mascara, lipstick, foundations, lotions, creams, and hairspray at 1-20%. Australian NICNAS full public report available confirming safety. The EU classifies Ethyl Trisiloxane as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Ethyl Trisiloxane allowed in the EU?
Ethyl Trisiloxane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Trisiloxane do in cosmetics?
Ethyl Trisiloxane functions as: Skin conditioning / Emollient (silicone derivative). It is classified as a cosmetic ingredient in our database. CAS number: 17861-60-8.
What is the Margin of Safety for Ethyl Trisiloxane?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethyl Trisiloxane?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Trisiloxane is 50 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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