Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Ethylene Brassylate (Macrocycle). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 30 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant safety concerns; environmentally favorable compared to polycyclic musks; no photoirritation concerns.
Regulatory Flags
Frequently Asked Questions
Is Ethylene Brassylate (Macrocycle) safe in cosmetics?
No significant safety concerns; environmentally favorable compared to polycyclic musks; no photoirritation concerns. The EU classifies Ethylene Brassylate (Macrocycle) as "permitted". Safety rating: EXCELLENT. 3 toxicological study endpoint(s) are available in our database.
Is Ethylene Brassylate (Macrocycle) allowed in the EU?
Ethylene Brassylate (Macrocycle) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylene Brassylate (Macrocycle) do in cosmetics?
Ethylene Brassylate (Macrocycle) functions as: Fragrance, Tonic (creates a pleasant feeling on skin/hair). It is classified as a cosmetic ingredient in our database. CAS number: 105-95-3.
What is the Margin of Safety for Ethylene Brassylate (Macrocycle)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethylene Brassylate (Macrocycle)?
The NOAEL (No Observed Adverse Effect Level) for Ethylene Brassylate (Macrocycle) is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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