Regulatory Status
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Safety Data
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Toxicological Studies
4 study endpoints found for Ethylhexyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 125 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=1070 mg/kg bw/day | dermal | rat | dermal | REACH |
| LOAEL | 7.5 other | 1991 | rat | inhalation | REACH |
| NOEL | 125 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Hydrolyzes to 2-ethylhexanol (CAS 104-76-7) which is classified Repr. 2 (H361d). Cumulative exposure to 2-ethylhexanol from all ester sources in formulation must be accounted for in CPSR. Also hydrolyzes to acetic acid (benign).
Regulatory Flags
Frequently Asked Questions
Is Ethylhexyl Acetate safe in cosmetics?
Hydrolyzes to 2-ethylhexanol (CAS 104-76-7) which is classified Repr. 2 (H361d). Cumulative exposure to 2-ethylhexanol from all ester sources in formulation must be accounted for in CPSR. Also hydrolyzes to acetic acid (benign). The EU classifies Ethylhexyl Acetate as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Ethylhexyl Acetate allowed in the EU?
Ethylhexyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexyl Acetate do in cosmetics?
Ethylhexyl Acetate functions as: Solvent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-09-3.
What is the Margin of Safety for Ethylhexyl Acetate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethylhexyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Acetate is 125 mg/kg bw/day based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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