Is Ethylhexyl Stearate safe in cosmetics?
Ethylhexyl Stearate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Ethylhexyl Stearate
Also known as: Isooctyl stearate, EINECS 244-754-0, Wickenol 156, UNII-EG3PA2K3K5, Octadecanoic acid, 2-ethylhexyl ester
INCI: ETHYLHEXYL STEARATE
Ethylhexyl Stearate (CAS 22047-49-0) is a cosmetic emollient functioning as Skin conditioning (emollient), solvent, dispersant. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 22047-49-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (emollient), solvent, dispersant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-ethylhexyl octadecanoate
InChIKey
OPJWPPVYCOPDCM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR safe as used when formulated to be non-irritating (2013). Up to 25% leave-on.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylhexyl Stearate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Ethylhexyl Stearate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
6 property records from structured ingredient metadata.
comedogenicity_detail
{"comedogenicity_rating": "2", "irritancy_rating": "0", "skin_type_suitability": "all,combination,normal", "acne_safe": "caution", "source": "Cosmetic formulation"}
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "11", "co_emulsifier_pairs": "polysorbate_60,steareth_20", "optimal_oil_phase_pct": "10-30", "optimal_water_phase_pct": "70-90", "droplet_size_range_um": "1-20", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "moderate", "rheology_modifier_type": "…
lipid
{"cas_number": "22047-49-0", "lipid_class": "ester", "botanical_source": "synthetic/derived", "plant_part": "derived", "extraction_method": "refined", "fatty_acid_profile_main_pct": "branched stearate", "omega_classification": "saturated", "comedogenicity_rating_0_5": "1", "absorption_rate": "fast", "skin_feel": "dry", "spreadability": "excellent", "occlusive_properties": "low", "emollient_grade":…
ph_stability
{"optimal_ph_min": "3.0", "optimal_ph_max": "10.0", "stable_ph_min": "3.0", "stable_ph_max": "11.0", "ph_dependent_function": "Emollient ester", "formulation_note": "Dry feel", "source": "Formulation literature"}
sensory
{"silky": "medium", "smooth, glides easily": "smooth, silky", "dry-touch, non-greasy": "soft, smooth", "instant": "moderate", "low": "medium", "w/o": "w/o", "very-high": "high", "no": "no", "yes": "no", "light-diffusing": "luminous", "1.40": "1.44", "transparent": "transparent", "colorless": "colorless", "excellent": "good", "light": "medium", "synthetic": "synthetic"}
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "hlb_required": "5.0", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "9.2", "appearance": "clear liquid", "source": "BASF"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Lubricating agent
Plasticizer
Softener and conditioner
Surfactant (surface active agent)
Regulatory List Membership (3)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethylhexyl Stearate.
Regulatory Flags
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethylhexyl Stearate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Isooctyl stearate
EINECS 244-754-0
Wickenol 156
UNII-EG3PA2K3K5
Octadecanoic acid, 2-ethylhexyl ester
Chemical Function
Surfactant (surface active agent)
Softener and conditioner
Fragrance
Plasticizer
Lubricating agent
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
Europe; Personal care - liniment
Europe; Personal care
Europe; Personal care
Europe; Personal care
consumer_product
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184927
Frequently Asked Questions
Is Ethylhexyl Stearate allowed in the EU?
Ethylhexyl Stearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexyl Stearate do in cosmetics?
Ethylhexyl Stearate functions as: Skin conditioning (emollient), solvent, dispersant. It is classified as a Emollient in our database. CAS number: 22047-49-0.
What is the NOAEL for Ethylhexyl Stearate?
The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Stearate is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Ethylhexyl Stearate used outside cosmetics?
Ethylhexyl Stearate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethylhexyl Stearate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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