Moderate Cosmetic Ingredient Dermal Penetration

Eucalyptus Oil

INCI: EUCALYPTUS OIL

CAS Number
8000-48-4
Function
Fragrance, masking agent, denaturant
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — no 21 CFR restriction; CIR Panel concluded safe in present practices of use when formulated to be non-sensitizing (2023)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Eucalyptus Oil, relevant to systemic exposure and MoS calculations.

Absorption %
18-32%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
154.3 Da
Log P
3.1
Systemic Absorption
yes
Topical Bioavailability
12-28%
Safety Margin Factor
very-high
Vehicle Dependent
Yes — absorption varies by formulation

Source: IFRA

Expert Verdict

Aspiration hazard (H304); penetration enhancer effect may increase absorption of co-formulated actives; must label constituent allergens above EU thresholds; oral toxicity of eucalyptol is significant (approximately 3-3.5 mL potentially fatal)

⚠️
Concern Level: High

Regulatory Flags

plant-oil potential-allergen fragrance-component eu_children_restricted ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Eucalyptus Oil safe in cosmetics?

Aspiration hazard (H304); penetration enhancer effect may increase absorption of co-formulated actives; must label constituent allergens above EU thresholds; oral toxicity of eucalyptol is significant (approximately 3-3.5 mL potentially fatal) The EU classifies Eucalyptus Oil as "restricted". Safety rating: MODERATE.

Is Eucalyptus Oil allowed in the EU?

Eucalyptus Oil EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Eucalyptus Oil do in cosmetics?

Eucalyptus Oil functions as: Fragrance, masking agent, denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 8000-48-4.

What is the Margin of Safety for Eucalyptus Oil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Eucalyptus Oil compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Veratraldehyde
Good
Trimethyl-1-Cyclohexenylacrylonitrile
Moderate
Carum Petroselinum Seed Oil
Moderate
2-Ethylbutyl Cyclopent-1-Eneacetate
Moderate
cis-3-Hexenyl 2-Methylbutyrate
Good
Browse all 30,000+ ingredients →
📱

Is Eucalyptus Oil in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Eucalyptus Oil in your formulation.

Ingredient Decoder MoS Calculator