Excellent Cosmetic Ingredient SCCS/CIR Reviewed

Glucosamine

INCI: GLUCOSAMINE

CAS Number
3416-24-8
Function
Skin conditioning agent; promotes hyaluronic acid synthesis, skin hydration, wound healing
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted, not restricted under 21 CFR for cosmetics; also a dietary supplement under DSHEA 1994; CIR Panel (2021 Draft Report) concluded safe as used when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe
NOAEL: 5 % (oral)

and concluded that these glucosamine ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. Keywords Safety, Cosmetics, Cosmetic Ingredient Review, Expert panel for Cosmetic Ingredient Safety,

Expert Verdict

Crustacean-derived grades may contain shellfish allergens; specify source (fungal/synthetic preferred for allergen-free claims). Oral LD50 > 15,000 mg/kg in mice. Formulate to be non-irritating per CIR conclusion.

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Concern Level: Low

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Glucosamine safe in cosmetics?

Crustacean-derived grades may contain shellfish allergens; specify source (fungal/synthetic preferred for allergen-free claims). Oral LD50 > 15,000 mg/kg in mice. Formulate to be non-irritating per CIR conclusion. The EU classifies Glucosamine as "permitted". Safety rating: EXCELLENT. This ingredient has been reviewed by cir.

Is Glucosamine allowed in the EU?

Glucosamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucosamine do in cosmetics?

Glucosamine functions as: Skin conditioning agent; promotes hyaluronic acid synthesis, skin hydration, wound healing. It is classified as a cosmetic ingredient in our database. CAS number: 3416-24-8.

What is the Margin of Safety for Glucosamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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