Regulatory Status
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Safety Data
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Expert Verdict
Hydrolyzes to glycolic acid in aqueous environment; pH of final product must be controlled (CIR recommends pH ≥3.5 for glycolic acid ≤10%). Potential confusion with 1,4-dioxane (a contaminant) due to similar ring name—not the same substance. Limited direct human patch-test data.
Frequently Asked Questions
Is Glycolide safe in cosmetics?
Hydrolyzes to glycolic acid in aqueous environment; pH of final product must be controlled (CIR recommends pH ≥3.5 for glycolic acid ≤10%). Potential confusion with 1,4-dioxane (a contaminant) due to similar ring name—not the same substance. Limited direct human patch-test data. The EU classifies Glycolide as "permitted". Safety rating: MODERATE.
Is Glycolide allowed in the EU?
Glycolide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycolide do in cosmetics?
Glycolide functions as: Skin conditioning agent; cyclic diester precursor of glycolic acid. It is classified as a cosmetic ingredient in our database. CAS number: 502-97-6.
What is the Margin of Safety for Glycolide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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