HC Blue No. 4

INCI: HC BLUE NO. 4

CAS Number
158571-57-4
Function
Hair dyeing — anthraquinone derivative (reaction product of N-methyl-1,4-diaminoanthraquinone with epichlorohydrin and monoethanolamine)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not explicitly prohibited by FDA; falls under coal tar hair dye exemption (21 CFR 740.2). However, Canada: PROHIBITED — Cosmetic Ingredient Hotlist.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU banned. Canada banned. Epichlorohydrin reaction product raises genotoxicity concerns. No manufacturer submitted adequate safety dossier to SCCS within the deadline. Do not formulate.

⚠️
Concern Level: High

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is HC Blue No. 4 safe in cosmetics?

EU banned. Canada banned. Epichlorohydrin reaction product raises genotoxicity concerns. No manufacturer submitted adequate safety dossier to SCCS within the deadline. Do not formulate. The EU classifies HC Blue No. 4 as "prohibited". Safety rating: POOR.

Is HC Blue No. 4 allowed in the EU?

HC Blue No. 4 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does HC Blue No. 4 do in cosmetics?

HC Blue No. 4 functions as: Hair dyeing — anthraquinone derivative (reaction product of N-methyl-1,4-diaminoanthraquinone with epichlorohydrin and monoethanolamine). It is classified as a cosmetic ingredient in our database. CAS number: 158571-57-4.

What is the Margin of Safety for HC Blue No. 4?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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