Hippuric Acid

INCI: HIPPURIC ACID

CAS Number
495-69-2
Function
Skin conditioning (N-Benzoylglycine; endogenous metabolite of benzoic acid)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS classification: H302 (harmful if swallowed), H315 (skin irritation), H318 (serious eye damage), H335 (respiratory irritation); requires strict concentration limits in formulation; eye-area products contraindicated without specific safety data; pH-dependent irritancy

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Concern Level: Moderate

Frequently Asked Questions

Is Hippuric Acid safe in cosmetics?

GHS classification: H302 (harmful if swallowed), H315 (skin irritation), H318 (serious eye damage), H335 (respiratory irritation); requires strict concentration limits in formulation; eye-area products contraindicated without specific safety data; pH-dependent irritancy The EU classifies Hippuric Acid as "permitted". Safety rating: MODERATE.

Is Hippuric Acid allowed in the EU?

Hippuric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hippuric Acid do in cosmetics?

Hippuric Acid functions as: Skin conditioning (N-Benzoylglycine; endogenous metabolite of benzoic acid). It is classified as a cosmetic ingredient in our database. CAS number: 495-69-2.

What is the Margin of Safety for Hippuric Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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