Is Butyrophenone safe in cosmetics?
Butyrophenone has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Butyrophenone
Also known as: EINECS 207-799-7, UNII-186I11WB5B
INCI: BUTYROPHENONE
Butyrophenone (CAS 495-40-9) is a cosmetic cosmetic ingredient functioning as Synthetic aromatic ketone used in fragrance chemistry. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 495-40-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butyrophenone is classified GHS Danger (H317, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Synthetic aromatic ketone used in fragrance chemistry
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1-phenylbutan-1-one
InChIKey
FFSAXUULYPJSKH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not established
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyrophenone.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Butyrophenone.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
EINECS 207-799-7
UNII-186I11WB5B
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
consumer_product
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BUTYROPHENONE
ChEMBL ID
CHEMBL193524
Frequently Asked Questions
Is Butyrophenone allowed in the EU?
Butyrophenone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyrophenone do in cosmetics?
Butyrophenone functions as: Synthetic aromatic ketone used in fragrance chemistry. It is classified as a cosmetic ingredient in our database. CAS number: 495-40-9.
Is Butyrophenone used outside cosmetics?
Butyrophenone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butyrophenone have different safety status in cosmetics vs industrial chemicals?
Butyrophenone is classified GHS Danger (H317, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Butyrophenone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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