Is Hyaluronic Acid safe in cosmetics?
Hyaluronic Acid has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Hyaluronic Acid
Also known as: EINECS 232-678-0, UNII-S270N0TRQY, Viscofill Extra, Hyalo-Oligo, Hyal-Joint (+6 more)
INCI: HYALURONIC ACID
Hyaluronic Acid (CAS 9004-61-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, humectant. EU Regulation 1223/2009 status: permitted; 2 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 9004-61-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, humectant
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction; also used as inactive ingredient in FDA-approved drugs at up to 0.01% topical
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hyaluronic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: unknown
NOAEL: 60 mg/kg (not specified)
cir
Verdict: unknown
NOAEL: 50 mg/kg (not specified)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| GCC | halal_restricted | - | All cosmetics |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 0.1–2 | 2 | CIR/VCRP |
| Face Cream | 0.05–1 | 2 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
biopolymer
{"cas_number": "9004-61-9", "polymer_class": "hyaluronic_acid", "botanical_source": "Acid form of sodium hyaluronate", "molecular_weight_range_kDa": "50-2000", "monosaccharide_composition": "glucuronic acid/N-acetylglucosamine (acid form)", "degree_of_branching": "linear", "charge_type": "anionic", "viscosity_1pct_solution_mPas": "pH_dependent", "pseudoplastic_behavior": "strong", "thixotropy": "y…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,sensitive,combination,normal,acne-prone,mature,rosacea", "acne_safe": "yes", "source": "Humectant"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "1.0", "typical_concentration_pct": "0.5", "product_type": "Moisturizer", "function_at_concentration": "Hydration", "source": "CIR Safety Assessment"}
interactions
{"ingredient_2": "Very low pH (<3)", "interaction_type": "destabilizing", "severity": "caution", "effect": "Acid hydrolysis of HA, loss of molecular weight", "recommendation": "Maintain pH >3.5 for HA stability", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
microbiome_impact
{"microbiome_effect": "positive", "prebiotic": "yes", "probiotic_compatible": "yes", "preservative_effect_on_microbiome": "Humectant; prebiotic properties; supports microbiome diversity", "gut_microbiome_risk": "low", "microbiome_recovery_time": "<2 days", "selective_antimicrobial": "no", "beneficial_bacteria_support": "S. epidermidis, Lactobacillus spp, Corynebacterium spp", "fermentation_derived…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "2.0", "adult_max_concentration_pct": "2.0", "pediatric_dermal_absorption_factor": "minimal", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_children_products_eu": "no", "banne…
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Naturally occurring; safe; hydrating", "source": "ACOG; dermatology literature"}
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Humectant
Softener and conditioner
Thickening agent
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Hyaluronic Acid.
Known Synonyms
EINECS 232-678-0
UNII-S270N0TRQY
Viscofill Extra
Hyalo-Oligo
Hyal-Joint
Macronan
Juvederm Voluma
Juvederm
Hyruan Plus
Hyalorigo
Hyaluronate
Chemical Function
Humectant
Anti-static agent
Softener and conditioner
Regulatory Lists
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
hyaluronic acid
ChEMBL ID
CHEMBL1697748
Adverse Event Associations
445
Frequently Asked Questions
Is Hyaluronic Acid allowed in the EU?
Hyaluronic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hyaluronic Acid do in cosmetics?
Hyaluronic Acid functions as: Skin conditioning agent, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 9004-61-9.
Is Hyaluronic Acid used outside cosmetics?
Hyaluronic Acid also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hyaluronic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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