Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Animal-sourced HA (rooster comb) must be free of pathogenic viruses, infectious agents, and biologically-derived impurities. Bacterial fermentation-derived HA is nearly endotoxin-free. No genotoxicity, no reproductive toxicity, acute oral LD50 >1200 mg/kg in mice.
Frequently Asked Questions
Is Hyaluronic Acid safe in cosmetics?
Animal-sourced HA (rooster comb) must be free of pathogenic viruses, infectious agents, and biologically-derived impurities. Bacterial fermentation-derived HA is nearly endotoxin-free. No genotoxicity, no reproductive toxicity, acute oral LD50 >1200 mg/kg in mice. The EU classifies Hyaluronic Acid as "permitted". Safety rating: EXCELLENT. This ingredient has been reviewed by cir.
Is Hyaluronic Acid allowed in the EU?
Hyaluronic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hyaluronic Acid do in cosmetics?
Hyaluronic Acid functions as: Skin conditioning agent, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 9004-61-9.
What is the Margin of Safety for Hyaluronic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Hyaluronic Acid compliance across multiple jurisdictions:
Related Ingredients
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