Is Hydrolyzed Silk safe in cosmetics?
Hydrolyzed Silk has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Hydrolyzed Silk
INCI: HYDROLYZED SILK
Hydrolyzed Silk (CAS 96690-41-4) is a cosmetic cosmetic ingredient functioning as hair conditioning, film-forming, moisture retention. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 96690-41-4 →
Auto-generated CPSR Part A draft with source citations
Function
hair conditioning, film-forming, moisture retention
Safety Rating
EXCELLENT
Chemistry & Identifiers
EC Number
306-235-8
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Panel reviewed 10 silk protein ingredients (including hydrolyzed fibroin, hydrolyzed sericin) and found them generally safe for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydrolyzed Silk.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Hydrolyzed Silk, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: CIR Expert Panel
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
7 property records from structured ingredient metadata.
amino_acid
{"cas_number": "96690-41-4", "ingredient_class": "silk_derivative", "source_origin": "animal", "molecular_weight_range_Da": "500-2000", "amino_acid_composition_key": "glycine_alanine_serine_rich", "isoelectric_point": "4.5", "charge_at_pH_5_5": "anionic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "excellent", "moisture_binding_capacity": "excellent", "NM…
baby_pediatric
{"cas_number": "96690-41-4", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "6", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Protein, conditioning", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Protein fragme…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal,mature", "acne_safe": "yes", "source": "Film former"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "5.0", "typical_concentration_pct": "3.0", "product_type": "Hair Serum", "function_at_concentration": "Smoothing, shine", "source": "Supplier TDS"}
dermal_absorption
{"molecular_weight_da": "Variable", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "low", "source": "CIR"}
polymer
{"cas_number": "96690-41-4", "ingredient_class": "conditioning/moisturizing", "polymer_type": "protein_based", "chemical_backbone": "protein", "molecular_weight_Da_range": "500-30000", "ionic_character": "nonionic", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_sensitivity": "moderate", "film_transparency…
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, glycerin, propylene glycol", "insoluble_in": "oils, ethanol, silicones", "log_p": "-3.5", "appearance": "clear to amber liquid", "source": "Ichimaru Pharcos"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Humectant
Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Hydrolyzed Silk.
Regulatory Flags
cir-approved
film-forming
moisture-binding
cosmos-eligible
natural
protein-hydrolysate
low-allergenicity
eu_children_restricted
Chemical Function
Humectant
Anti-static agent
Softener and conditioner
Regulatory Lists
Europe; Personal care
Europe; Personal care
children; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydrolyzed Silk allowed in the EU?
Hydrolyzed Silk EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrolyzed Silk do in cosmetics?
Hydrolyzed Silk functions as: hair conditioning, film-forming, moisture retention. It is classified as a cosmetic ingredient in our database. CAS number: 96690-41-4.
Is Hydrolyzed Silk used outside cosmetics?
Hydrolyzed Silk also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydrolyzed Silk compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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