Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Hydroxylamine HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 233 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 3.29 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 7.77 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Suspected carcinogen with skin sensitization hazard; harmful via oral and dermal routes with organ damage upon prolonged exposure; mutagenic in mouse lymphoma assay and highly toxic to aquatic organisms.
Regulatory Flags
Frequently Asked Questions
Is Hydroxylamine HCl safe in cosmetics?
Suspected carcinogen with skin sensitization hazard; harmful via oral and dermal routes with organ damage upon prolonged exposure; mutagenic in mouse lymphoma assay and highly toxic to aquatic organisms. The EU classifies Hydroxylamine HCl as "prohibited". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.
Is Hydroxylamine HCl allowed in the EU?
Hydroxylamine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxylamine HCl do in cosmetics?
Hydroxylamine HCl functions as: Antioxidant / Reducing agent. It is classified as a cosmetic ingredient in our database. CAS number: 5470-11-1.
What is the Margin of Safety for Hydroxylamine HCl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxylamine HCl?
The NOAEL (No Observed Adverse Effect Level) for Hydroxylamine HCl is 233 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Is Hydroxylamine HCl classified as hazardous under GHS?
Hydroxylamine HCl carries a GHS signal word of "DANGER". Hazard statements: May be osive to metals Toxic if swallowed Harmful in contact with skin Causes skin and eye irritation May cause an allergic skin reaction Suspected of causing cancer May cause damage to blood May cause damage to blood through prolonged or repeated exposure Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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