Is Hydroxypalmitoyl Sphinganine safe in cosmetics?
Hydroxypalmitoyl Sphinganine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Hydroxypalmitoyl Sphinganine
INCI: HYDROXYPALMITOYL SPHINGANINE
Hydroxypalmitoyl Sphinganine (CAS 103819-46-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Hair Conditioning, Barrier Repair. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 103819-46-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Hair Conditioning, Barrier Repair
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel 2020 concluded safe at reported use concentrations of 0.0025-0.062%; functions as a ceramide precursor to restore barrier integrity
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxypalmitoyl Sphinganine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Emulsifier
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxypalmitoyl Sphinganine.
Regulatory Flags
ceramide
barrier-repair
CIR-reviewed
skin-conditioning
hair-conditioning
Chemical Function
Surfactant (surface active agent)
Softener and conditioner
Emulsifier
Regulatory Lists
Canada
Personal care
Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydroxypalmitoyl Sphinganine allowed in the EU?
Hydroxypalmitoyl Sphinganine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxypalmitoyl Sphinganine do in cosmetics?
Hydroxypalmitoyl Sphinganine functions as: Skin Conditioning, Hair Conditioning, Barrier Repair. It is classified as a cosmetic ingredient in our database. CAS number: 103819-46-1.
Compliance Tools
Check Hydroxypalmitoyl Sphinganine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acacia Decurrens/Jojoba/Sunflower Seed Wax Polyglyceryl-3 Esters
Excellent
Same category
Skin conditioning emollient, texturizer
Acetic/Linoleic/Palmitic Triglyceride
Excellent
Same category
Skin conditioning (emollient)
Acetyl Ornithine
Excellent
Same category
Emollient
Acetyl Proline
Excellent
Same category
Emollient
Acetyl Triethylhexyl Citrate
Excellent
Same category
Emollient, Film Forming, Plasticiser
Acetyl Trihexyl Citrate
Excellent
Same category
Plasticiser, Skin Conditioning (Emoll...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
OLIVE OIL PEG-10 ESTERS
Good
Chemical family
Skin Conditioning - Emollient, Surfac...
OLIVE OIL PEG-6 ESTERS
Good
Chemical family
Skin Conditioning - Emollient
OLIVE OIL PEG-7 ESTERS
Good
Chemical family
Skin Conditioning - Emollient, Surfac...
Is Hydroxypalmitoyl Sphinganine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydroxypalmitoyl Sphinganine in your formulation.