Hydroxypalmitoyl Sphinganine

INCI: HYDROXYPALMITOYL SPHINGANINE

CAS Number
103819-46-1
Function
Skin Conditioning, Hair Conditioning, Barrier Repair
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR Expert Panel 2020 concluded safe at reported use concentrations of 0.0025-0.062%; functions as a ceramide precursor to restore barrier integrity

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Synthetic ceramide precursor that stimulates endogenous ceramide production; clinically validated to improve hydration, reduce TEWL, and benefit atopic skin; CIR-reviewed and concluded safe; ideal for barrier-repair formulations

โš ๏ธ
Concern Level: None

Regulatory Flags

ceramide barrier-repair CIR-reviewed skin-conditioning hair-conditioning

Frequently Asked Questions

Is Hydroxypalmitoyl Sphinganine safe in cosmetics?

Synthetic ceramide precursor that stimulates endogenous ceramide production; clinically validated to improve hydration, reduce TEWL, and benefit atopic skin; CIR-reviewed and concluded safe; ideal for barrier-repair formulations The EU classifies Hydroxypalmitoyl Sphinganine as "permitted". Safety rating: EXCELLENT.

Is Hydroxypalmitoyl Sphinganine allowed in the EU?

Hydroxypalmitoyl Sphinganine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypalmitoyl Sphinganine do in cosmetics?

Hydroxypalmitoyl Sphinganine functions as: Skin Conditioning, Hair Conditioning, Barrier Repair. It is classified as a cosmetic ingredient in our database. CAS number: 103819-46-1.

What is the Margin of Safety for Hydroxypalmitoyl Sphinganine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Hydroxypalmitoyl Sphinganine in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydroxypalmitoyl Sphinganine in your formulation.