Is Indocyanine Green safe in cosmetics?
Indocyanine Green has a safety rating of "POOR" in our database. EU status: permitted. US status: restricted.
POOR
Cosmetic Ingredient
Indocyanine Green
INCI: INDOCYANINE GREEN
Indocyanine Green (CAS 3599-32-4 / EC 222-751-5) is a cosmetic cosmetic ingredient functioning as Colorant, diagnostic dye. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 3599-32-4 / EC 222-751-5 →
Function
Colorant, diagnostic dye
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
FDA-approved as injectable diagnostic drug (21 CFR) but not listed as permitted color additive for cosmetics under 21 CFR Parts 73, 74, or 82
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Indocyanine Green.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Indocyanine Green — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
colorant
Frequently Asked Questions
Is Indocyanine Green allowed in the EU?
Indocyanine Green EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Indocyanine Green do in cosmetics?
Indocyanine Green functions as: Colorant, diagnostic dye. It is classified as a cosmetic ingredient in our database. CAS number: 3599-32-4 / EC 222-751-5.
Compliance Tools
Check Indocyanine Green compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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