Is Isoamylbenzoate safe in cosmetics?
Isoamylbenzoate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isoamylbenzoate
Also known as: Isoamyl benzoate, Benzoic acid, 1-(3-methyl)butyl ester, BRN 1946447, EINECS 202-334-4, FEMA No. 2058 (+6 more)
INCI: ISOAMYLBENZOATE
Isoamylbenzoate (CAS 94-46-2) is a cosmetic cosmetic ingredient functioning as Fragrance (parfum). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 94-46-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (parfum)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methylbutyl benzoate
InChIKey
MLLAPOCBLWUFAP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics; also GRAS as a food flavoring agent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isoamylbenzoate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3888 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
857
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYLBUTYL BENZOATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/73 | FAS 48-JECFA 57/227
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOAMYL BENZOATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/73 | FAS 48-JECFA 57/227
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isoamylbenzoate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Isoamyl benzoate
Benzoic acid, 1-(3-methyl)butyl ester
BRN 1946447
EINECS 202-334-4
FEMA No. 2058
Isopentyl alcohol, benzoate
1-(3-Methyl)butyl benzoate
3-Methylbutyl benzoate
3-Methyl-1-butyl benzoate
NSC 9284
UNII-0AY72CK43K
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BENZOIC ACID 1-(3-METHYL)BUTYL ESTER
ChEMBL ID
CHEMBL2260711
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOAMYL BENZOATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isoamylbenzoate allowed in the EU?
Isoamylbenzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoamylbenzoate do in cosmetics?
Isoamylbenzoate functions as: Fragrance (parfum). It is classified as a cosmetic ingredient in our database. CAS number: 94-46-2.
Is Isoamylbenzoate used outside cosmetics?
Isoamylbenzoate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isoamylbenzoate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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