Isobornyl Acetate

INCI: ISOBORNYL ACETATE

CAS Number
125-12-2 [^1_12][^1_6]
Function
Fragrance (perfuming) — piney, balsamic terpene ester
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — FEMA GRAS; no restriction under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Well-characterized fragrance ingredient with negative genotoxicity findings (Ames and in vivo micronucleus tests); not PBT; kidney changes observed in male rats at high doses attributed to species-specific nephropathy not relevant to human safety.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Isobornyl Acetate safe in cosmetics?

Well-characterized fragrance ingredient with negative genotoxicity findings (Ames and in vivo micronucleus tests); not PBT; kidney changes observed in male rats at high doses attributed to species-specific nephropathy not relevant to human safety. The EU classifies Isobornyl Acetate as "permitted". Safety rating: EXCELLENT.

Is Isobornyl Acetate allowed in the EU?

Isobornyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isobornyl Acetate do in cosmetics?

Isobornyl Acetate functions as: Fragrance (perfuming) — piney, balsamic terpene ester. It is classified as a cosmetic ingredient in our database. CAS number: 125-12-2 [^1_12][^1_6].

What is the Margin of Safety for Isobornyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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