Is ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER safe in cosmetics?
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER
Also known as: Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-, 2,2-Bis(p-(2,3-epoxypropoxy)phenyl)propane, 2,2-Bis(4-(2,3-epoxypropyloxy)phenyl)propane, Bis(4-glycidyloxyphenyl)dimethylmethane, 2,2-Bis(p-hydroxyphenyl)propane, diglycidyl ether (+15 more)
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER (CAS 1675-54-3) is a cosmetic cosmetic ingredient functioning as Not Reported. Reported NOAEL =100 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1675-54-3 →
Auto-generated CPSR Part A draft with source citations
Function
Not Reported
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
InChIKey
LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin. Exposure could cause lowering of consciousness.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
47, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
Eye Irrit. 2; H319: C ≥ 5.0%; Skin Irrit. 2; H315: C ≥ 5.0%
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
58.65%
DPRA Lys %
2.15%
KeratinoSens IC50
21.95 µM
hCLAT CV75
36 µg/mL
LLNA EC3
1.5%
NESIL
375 µg/cm²
LLNA: Strong (1A)
GHS: 1A
Source: LLNA: Gerberick et al. (2005); DPRA: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Takenouchi personal communication (undated); KS: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Delaine et al. 2011 [DOI:10.1021/tx200196s]; hCLAT: Takenouchi et al. 2013 [DOI:10.2131/jts.38.599]
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Under investigation
Evidence: Limited
(2022)
Health effects: Yes
Affected pathways: Estrogenic
Regulatory framework: REACH
Source list: II (former)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (5)
Carcinogen Classification
Bisphenol A diglycidyl ether (Araldite) | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 47: (1989) Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of bisphenol A diglycidyl ether were available. There is limited evidence in experimental animals for the carcinogenicity of bisphenol A diglycidyl ether. Overall evaluation: Bisphenol A diglycidyl ether is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0151
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Dermal contact is the usual mode of exposure, but droplets in mist can also attack the eyes and respiratory tract. Glycidyl and diglycidyl ethers tend to be irritants and sensitizing agents. /Glycidyl and diglycidyl ethers/ | /Glycidyl ethers/ are primary skin and eye irritants and may cause sensitization. /Glycidyl ethers/ | ... As curing agents for epoxy resins, polyfunctional primary aliphatic
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER by CAS number or substance name.
Studies
1
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-
2,2-Bis(p-(2,3-epoxypropoxy)phenyl)propane
2,2-Bis(4-(2,3-epoxypropyloxy)phenyl)propane
Bis(4-glycidyloxyphenyl)dimethylmethane
2,2-Bis(p-hydroxyphenyl)propane, diglycidyl ether
2,2-Bis(4-hydroxyphenyl)propane, diglycidyl ether
Diglycidyl bisphenol A
Diglycidyl ether of 2,2-bis(p-hydroxyphenyl)propane
Diglycidyl ether of 2,2-bis(4-hydroxyphenyl)propane
Diglycidyl ether of bisphenol A
Diglycidyl ether of 4,4'-isopropylidenediphenol
p,p'-Dihydroxydiphenyldimethylmethane diglycidyl ether
4,4'-Dihydroxydiphenyldimethylmethane diglycidyl ether
EINECS 216-823-5
Epoxide A
4,4'-Isopropylidenebis(1-(2,3-epoxypropoxy)benzene)
Oligomer 340
Propane, 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-
Dian-bis-glycidylether
UNII-F3XRM1NX4H
Chemical Function
No specific technical function
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; non_food_use; Pesticides
CEDI
Canada; pharmaceutical
Canada; pharmaceutical
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL258558
Frequently Asked Questions
Is ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER allowed in the EU?
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER do in cosmetics?
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 1675-54-3.
What is the NOAEL for ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER?
The NOAEL (No Observed Adverse Effect Level) for ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER is =100 mg/kg bw/day based on a chronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER used outside cosmetics?
ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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