Also known as: Henna
INCI: LAWSONIA INERMIS CALLUS CULTURE EXTRACT
Lawsonia Inermis Callus Culture Extract (CAS 84988-66-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, hair dyeing, antimicrobial, antioxidant. Reported NOAEL =40 mg/kg bw (SCCNFP_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84988-66-9 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Lawsonia Inermis Callus Culture Extract.
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10 study endpoints found for Lawsonia Inermis Callus Culture Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP_vision_codex |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP_vision_codex |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.2% | - | - | SCCP/0034 |
| measured | 0.28% | in_vitro | - | SCCP/0034 |
| measured | 1.4% | - | - | SCCP/0034 |
| measured | 0.34% | - | - | SCCP/0034 |
| measured | 3.1% | - | - | SCCP/0034 |
Expert safety assessment and concern-level summary for Lawsonia Inermis Callus Culture Extract.
Public NOAEL study rows linked to Lawsonia Inermis Callus Culture Extract by CAS number or substance name.
Units vary across source rows: mg/kg bw, mg/kg/day, mg/kg bw/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.2% | - | - |
| 0.28% | in_vitro | - |
| 1.4% | - | - |
| 0.34% | - | - |
| 3.1% | - | - |
Lawsonia Inermis Callus Culture Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Lawsonia Inermis Callus Culture Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Lawsonia Inermis Callus Culture Extract functions as: Skin conditioning, hair conditioning, hair dyeing, antimicrobial, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 84988-66-9.
The NOAEL (No Observed Adverse Effect Level) for Lawsonia Inermis Callus Culture Extract is =40 mg/kg bw based on a irritation study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Lawsonia Inermis Callus Culture Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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