Also known as: Henna
INCI: LAWSONIA INERMIS CALLUS CULTURE EXTRACT
Lawsonia Inermis Callus Culture Extract (CAS 84988-66-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, hair dyeing, antimicrobial, antioxidant. Reported NOAEL =40 mg/kg bw (SCCNFP Opinion); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84988-66-9 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Lawsonia Inermis Callus Culture Extract.
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10 study endpoints found for Lawsonia Inermis Callus Culture Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP Opinion |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP Opinion |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.2% | - | - | SCCP/0034 |
| measured | 0.28% | in_vitro | - | SCCP/0034 |
| measured | 1.4% | - | - | SCCP/0034 |
| measured | 0.34% | - | - | SCCP/0034 |
| measured | 3.1% | - | - | SCCP/0034 |
Preliminary editorial summary for Lawsonia Inermis Callus Culture Extract — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Lawsonia Inermis Callus Culture Extract by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.2% | - | - |
| 0.28% | in_vitro | - |
| 1.4% | - | - |
| 0.34% | - | - |
| 3.1% | - | - |
Lawsonia Inermis Callus Culture Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Lawsonia Inermis Callus Culture Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Lawsonia Inermis Callus Culture Extract functions as: Skin conditioning, hair conditioning, hair dyeing, antimicrobial, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 84988-66-9.
The NOAEL (No Observed Adverse Effect Level) for Lawsonia Inermis Callus Culture Extract is =40 mg/kg bw based on a irritation study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Lawsonia Inermis Callus Culture Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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