Excellent Cosmetic Ingredient NOAEL Data GHS Classified

Magnesium Aluminum Silicate

INCI: MAGNESIUM ALUMINUM SILICATE

CAS Number
1302-78-9
Function
rheology modifier, thickener, suspending agent, stabilizer
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted cosmetic ingredient with no FDA concentration limits. Also recognized as OTC antacid active ingredient under 21 CFR 331.11(g)(3) and 331.11(l)(1). CIR safety assessment supports use at concentrations up to 11%.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Magnesium Aluminum Silicate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 400 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 75000 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 400 mg/kg bw/day oral swine Short Term Toxicity COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 400 mg/kg bw/day oral swine Short Term Toxicity COSMOS_DB
dose_tested 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
cancer;health haz
Hazard Statements
Causes damage to the lungs through prolonged or repeated exposure if inhaled
Short-term Exposure Effects
The substance is mildly irritating to the eyes and skin.
Long-term Exposure Effects
The substance may have effects on the lungs. This may result in fibrosis (see ICSC 0808).
Routes of Exposure
The substance can be absorbed into the body by inhalation.

Expert Verdict

Magnesium Aluminum Silicate is safe as used in cosmetic formulations when formulated to be non-irritating. CIR Expert Panel confirmed safety at concentrations up to 11%. EU: not prohibited or restricted under EC 1223/2009. US: permitted cosmetic ingredient and OTC antacid active. Inhalation data insufficient for spray products with naturally-sourced forms due to potential crystalline silica content (1-6%).

⚠️
Concern Level: Low

Regulatory Flags

eu-unrestricted cir-approved non-sensitizing eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Magnesium Aluminum Silicate safe in cosmetics?

Magnesium Aluminum Silicate is safe as used in cosmetic formulations when formulated to be non-irritating. CIR Expert Panel confirmed safety at concentrations up to 11%. EU: not prohibited or restricted under EC 1223/2009. US: permitted cosmetic ingredient and OTC antacid active. Inhalation data insufficient for spray products with naturally-sourced forms due to potential crystalline silica content (1-6%). The EU classifies Magnesium Aluminum Silicate as "permitted". Safety rating: EXCELLENT. 6 toxicological study endpoint(s) are available in our database.

Is Magnesium Aluminum Silicate allowed in the EU?

Magnesium Aluminum Silicate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Magnesium Aluminum Silicate do in cosmetics?

Magnesium Aluminum Silicate functions as: rheology modifier, thickener, suspending agent, stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 1302-78-9.

What is the Margin of Safety for Magnesium Aluminum Silicate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Magnesium Aluminum Silicate?

The NOAEL (No Observed Adverse Effect Level) for Magnesium Aluminum Silicate is 400 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.

Is Magnesium Aluminum Silicate classified as hazardous under GHS?

Magnesium Aluminum Silicate carries a GHS signal word of "DANGER". Hazard statements: Causes damage to the lungs through prolonged or repeated exposure if inhaled. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Magnesium Aluminum Silicate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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