Melaleuca Alternifolia (Tea Tree) Leaf Oil
INCI: MELALEUCA ALTERNIFOLIA LEAF OIL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Melaleuca Alternifolia (Tea Tree) Leaf Oil. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 30 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 25 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 20 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 20 mg/kg bw/day | oral | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | oral | - | subchronic | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | - | rat | - | SCCS_PDF_extraction |
| NOAEL | 20 mg/kg bw/day | oral | rat | - | SCCS_PDF_extraction |
| NOAEL | 250 mg/kg bw/day | oral | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 0.117 mg/kg bw/day | oral | rat | - | SCCS_PDF_extraction |
| NOAEL | 250 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for Melaleuca Alternifolia (Tea Tree) Leaf Oil based on clinical patch test studies and IFRA standards.
Source: IVDK
Expert Verdict
Good safety profile with established use in cosmetics; generally considered safe for topical application.
Regulatory Flags
Frequently Asked Questions
Is Melaleuca Alternifolia (Tea Tree) Leaf Oil safe in cosmetics?
Good safety profile with established use in cosmetics; generally considered safe for topical application. The EU classifies Melaleuca Alternifolia (Tea Tree) Leaf Oil as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is Melaleuca Alternifolia (Tea Tree) Leaf Oil allowed in the EU?
Melaleuca Alternifolia (Tea Tree) Leaf Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Melaleuca Alternifolia (Tea Tree) Leaf Oil do in cosmetics?
Melaleuca Alternifolia (Tea Tree) Leaf Oil functions as: Emollient. It is classified as a Emollient in our database. CAS number: 68647-73-4.
What is the Margin of Safety for Melaleuca Alternifolia (Tea Tree) Leaf Oil?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Melaleuca Alternifolia (Tea Tree) Leaf Oil?
The NOAEL (No Observed Adverse Effect Level) for Melaleuca Alternifolia (Tea Tree) Leaf Oil is 30 mg/kg bw/day based on a toxicological study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_PDF_extraction.
Compliance Tools
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