Is Menthone Glycerin Acetal safe in cosmetics?
Menthone Glycerin Acetal has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Menthone Glycerin Acetal
Also known as: Menthone 1,2-glyceryl ketal, (9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol
INCI: MENTHONE GLYCERIN ACETAL
Menthone Glycerin Acetal (CAS 63187-91-7) is a cosmetic cosmetic ingredient functioning as Refreshing/cooling agent. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 63187-91-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Menthone Glycerin Acetal is classified GHS Danger (H315, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Refreshing/cooling agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(6S,9R)-9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl]methanol
InChIKey
ZBJCYZPANVLBRK-IGJPJIBNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
RIFM (Research Institute for Fragrance Materials): Safe as described (2024 assessment); IFRA compliant
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Menthone Glycerin Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Menthone Glycerin Acetal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Skin Irrit. 2; Eye Dam. 1; Aquatic Chronic 3
Hazard Statements
- H315 Causes skin irritation
- H318 Causes serious eye damage
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
445
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(-)-MENTHONE 1,2-GLYCEROL KETAL | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/111 | FAS 42-JECFA 51/381
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
FRESCOLAT, TYPE MGA | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/111 | FAS 42-JECFA 51/381
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Menthone Glycerin Acetal.
Regulatory Flags
potential-allergen
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Menthone Glycerin Acetal by CAS number or substance name.
Studies
1
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Menthone 1,2-glyceryl ketal
(9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol
Chemical Function
Flavouring and nutrient
Fragrance
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Menthone Glycerin Acetal allowed in the EU?
Menthone Glycerin Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthone Glycerin Acetal do in cosmetics?
Menthone Glycerin Acetal functions as: Refreshing/cooling agent. It is classified as a cosmetic ingredient in our database. CAS number: 63187-91-7.
What is the NOAEL for Menthone Glycerin Acetal?
The NOAEL (No Observed Adverse Effect Level) for Menthone Glycerin Acetal is =200 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Menthone Glycerin Acetal used outside cosmetics?
Menthone Glycerin Acetal also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Menthone Glycerin Acetal have different safety status in cosmetics vs industrial chemicals?
Menthone Glycerin Acetal is classified GHS Danger (H315, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Menthone Glycerin Acetal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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