Moderate Cosmetic Ingredient NOAEL Data

Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate

INCI: METHOXYPROPYLAMINO CYCLOHEXENYLIDENE ETHOXYETHYLCYANOACETATE

CAS Number
1419401-88-9
Function
UV Filter (absorbs UVA radiation); Light Stabilizer
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not currently listed among FDA-approved OTC sunscreen actives (21 CFR 352); would require NDA or GRASE determination for sunscreen use in the US

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 250 mg/kg bw/day oral - 90-day oral, rat SCCS_Perplexity

Expert Verdict

The SCCS evaluated its safety dossier; it is a cyclic merocyanine compound - photostability and potential skin sensitization were examined during the opinion process. Marketed as Mexoryl 400 by L'Oréal; co-developed with BASF; absorption maximum at 385 nm (UVA1 range, 360-400 nm); yellow solid, soluble in phenoxyethanol, ethoxydiglycol, dimethyl isosorbide, and ethanol

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate safe in cosmetics?

The SCCS evaluated its safety dossier; it is a cyclic merocyanine compound - photostability and potential skin sensitization were examined during the opinion process. Marketed as Mexoryl 400 by L'Oréal; co-developed with BASF; absorption maximum at 385 nm (UVA1 range, 360-400 nm); yellow solid, soluble in phenoxyethanol, ethoxydiglycol, dimethyl isosorbide, and ethanol The EU classifies Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate allowed in the EU?

Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate do in cosmetics?

Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate functions as: UV Filter (absorbs UVA radiation); Light Stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 1419401-88-9.

What is the Margin of Safety for Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate?

The NOAEL (No Observed Adverse Effect Level) for Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate is 250 mg/kg bw/day based on a 90-day oral, rat study via oral route in rat. Source: SCCS_Perplexity.

📱

Is Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate in your formulation.