Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Methyl Acetamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 190 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Major concern - classified as reprotoxic in the EU (Repr. 1B, H360D - may damage the unborn child); this is the primary reason for its severely restricted/prohibited status in EU cosmetics. Excellent solvent properties; miscible with water; low molecular weight amide
Regulatory Flags
Frequently Asked Questions
Is Methyl Acetamide safe in cosmetics?
Major concern - classified as reprotoxic in the EU (Repr. 1B, H360D - may damage the unborn child); this is the primary reason for its severely restricted/prohibited status in EU cosmetics. Excellent solvent properties; miscible with water; low molecular weight amide The EU classifies Methyl Acetamide as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Methyl Acetamide allowed in the EU?
Methyl Acetamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Acetamide do in cosmetics?
Methyl Acetamide functions as: Solvent, hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 79-16-3.
What is the Margin of Safety for Methyl Acetamide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Acetamide?
The NOAEL (No Observed Adverse Effect Level) for Methyl Acetamide is 50 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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