Is Methyl Acetamide safe in cosmetics?
Methyl Acetamide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Methyl Acetamide
Also known as: Acetamide, methyl-, Acetic acid, amide, N-methyl, EINECS 201-182-6, N-Monomethylacetamide, UNII-V0T777481M (+2 more)
INCI: METHYL ACETAMIDE (N-METHYLACETAMIDE)
Methyl Acetamide (CAS 79-16-3) is a cosmetic cosmetic ingredient functioning as Solvent, hair conditioning agent. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 79-16-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methyl Acetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H360, H360D, H361).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent, hair conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N-methylacetamide
InChIKey
OHLUUHNLEMFGTQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Allowed - FDA does not maintain a comprehensive prohibited list equivalent to the EU's for most solvents; however, manufacturers bear responsibility for product safety
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Acetamide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Methyl Acetamide across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Repr. 1B
Hazard Statements
- H360D ***
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 19-Dec-2012)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Toxic for reproduction (Article 57c)
Substance of Very High Concern (SVHC)
Included: 19-Dec-2012
Toxic for reproduction (Article 57c)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 745
(EC) 2009/1223
CMR: Reprotoxic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 745
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Acetamide.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Acetamide, methyl-
Acetic acid, amide, N-methyl
EINECS 201-182-6
N-Monomethylacetamide
UNII-V0T777481M
Acetylmethylamine
N-Acetyl-N-methylamine
Chemical Function
No specific technical function
Regulatory Lists
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL11544
Frequently Asked Questions
Is Methyl Acetamide allowed in the EU?
Methyl Acetamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Acetamide do in cosmetics?
Methyl Acetamide functions as: Solvent, hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 79-16-3.
Is Methyl Acetamide used outside cosmetics?
Methyl Acetamide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methyl Acetamide have different safety status in cosmetics vs industrial chemicals?
Methyl Acetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H360, H360D, H361).
Compliance Tools
Check Methyl Acetamide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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