Is Methyl Amyl Ketone safe in cosmetics?
Methyl Amyl Ketone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Methyl Amyl Ketone
Also known as: 1-Methylhexanal, 2-Oxoheptane, Amyl methyl ketone, Butylacetone, Methyl n-amyl ketone (+11 more)
INCI: METHYL AMYL KETONE (SYNONYM: 2-HEPTANONE)
Methyl Amyl Ketone (CAS 110-43-0) is a cosmetic cosmetic ingredient functioning as Solvent, Fragrance ingredient. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-43-0 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
heptan-2-one
InChIKey
CATSNJVOTSVZJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed. Also has FEMA GRAS status (FEMA 2544) for flavor use, indicating a well-characterized safety profile
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Amyl Ketone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Methyl Amyl Ketone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Methyl Amyl Ketone across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *
Hazard Statements
- H226 Flammable liquid and vapour
- H332 Harmful if inhaled
- H302 Harmful if swallowed
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0920
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Vapor: Irritating to eyes, nose and throat. Liquid: Irritating to skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
283
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-HEPTANONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL AMYL KETONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Amyl Ketone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Methyl Amyl Ketone by CAS number or substance name.
Studies
1
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
COSMOS_DB
Known Synonyms
1-Methylhexanal
2-Oxoheptane
Amyl methyl ketone
Butylacetone
Methyl n-amyl ketone
Methyl pentyl ketone
Pentyl methyl ketone
4-01-00-03318
BRN 1699063
EINECS 203-767-1
FEMA Number 2544
Ketone, methyl pentyl
Methyl-n-amylketone
Amyl-methyl-cetone
Methyl-amyl-cetone
UNII-89VVP1B008
Chemical Function
Fragrance
Flavouring and nutrient
Solvent
Regulatory Lists
artificial_sweat; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Other direct contact consumer goods
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
inert_ingredient; non_food_use; Pesticides
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL18893
Frequently Asked Questions
Is Methyl Amyl Ketone allowed in the EU?
Methyl Amyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Amyl Ketone do in cosmetics?
Methyl Amyl Ketone functions as: Solvent, Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 110-43-0.
What is the NOAEL for Methyl Amyl Ketone?
The NOAEL (No Observed Adverse Effect Level) for Methyl Amyl Ketone is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Is Methyl Amyl Ketone used outside cosmetics?
Methyl Amyl Ketone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Amyl Ketone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
1,4-Butanediol
Poor
Chemical family
Solvent, humectant, viscosity control...
2-Ethoxyethanol
Poor
Chemical family
Solvent
2-Methyldodecanal
Moderate
Chemical family
Fragrance ingredient with aldehydic, ...
Is Methyl Amyl Ketone in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methyl Amyl Ketone in your formulation.