Also known as: UNII-8NT850T0YS
INCI: METHYLENE BIS BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti (CAS 103597-45-1) is a cosmetic cosmetic ingredient functioning as UV filter. Reported NOAEL =0.0144 mg/kg bw/d in rat (SCCS Opinion); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 103597-45-1 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS Opinion |
| NOAEL | =800 mg/kg bw/d | dermal | rat | NOAEL study | SCCS Opinion |
| NOAEL | =800 mg/kg bw | dermal | rat | carcinogenicity | SCCS Opinion |
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
no significant ER/AR activity
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| BR | permitted_uv_filter | 10 | Sunscreen products; only non-nano form |
| ASEAN | permitted_uv_filter | 10% | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.07% | in_vitro | - | SCCS/0168 |
| measured | 10.0% | - | - | SCCS/0168 |
| measured | 0.048% | - | - | SCCS/0168 |
| default | 0.35% | - | - | SCCS/0168 |
| default | 5.92% | - | - | SCCS/0168 |
Expert safety assessment and concern-level summary for Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti.
Public NOAEL study rows linked to Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.07% | in_vitro | - |
| 10.0% | - | - |
| 0.048% | - | - |
| 0.35% | - | - |
| 5.92% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti functions as: UV filter. It is classified as a cosmetic ingredient in our database. CAS number: 103597-45-1.
The NOAEL (No Observed Adverse Effect Level) for Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti is =0.0144 mg/kg bw/d based on a dermal absorption study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Methylene Bis Benzotriazolyl Tetramethylbutylphenol (Ti also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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