INCI: METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) (CAS 103597-45-1) is a cosmetic uv filter / sunscreen functioning as UV filter. Reported NOAEL =0.0144 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: permitted, max 6%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 103597-45-1 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M).
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10 study endpoints found for Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0144 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =59.2 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =800 mg/kg bw/d | dermal | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =800 mg/kg bw | dermal | rat | carcinogenicity | SCCS_vision_codex |
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
no significant ER/AR activity
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| BR | permitted_uv_filter | 10 | Sunscreen products; only non-nano form |
| ASEAN | permitted_uv_filter | 10% | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.07% | in_vitro | - | SCCS/0168 |
| measured | 10.0% | - | - | SCCS/0168 |
| measured | 0.048% | - | - | SCCS/0168 |
| default | 0.35% | - | - | SCCS/0168 |
| default | 5.92% | - | - | SCCS/0168 |
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Sunscreen | 2–10 | 10 | SCCS |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M).
Public NOAEL study rows linked to Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.07% | in_vitro | - |
| 10.0% | - | - |
| 0.048% | - | - |
| 0.35% | - | - |
| 5.92% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) EU regulatory status: permitted. Maximum allowed concentration: 6%. This is based on EU Regulation 1223/2009 and its amendments.
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) functions as: UV filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 103597-45-1.
The NOAEL (No Observed Adverse Effect Level) for Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) is =0.0144 mg/kg bw/d based on a dermal absorption study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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