Myristoyl Tetrapeptide-12

INCI: MYRISTOYL TETRAPEPTIDE-12

CAS Number
959610-24-3
Function
Skin conditioning, hair growth stimulation (eyelash/eyebrow enhancement, keratinocyte proliferation)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR safety assessment covers Myristoyl Tetrapeptide-12 specifically; the CIR 2018 report covers related myristoyl/palmitoyl peptides but explicitly excludes the KAKA sequence. No FDA OTC monograph applies. Under MoCRA, ingredient is reportable as a cosmetic ingredient with no current FDA-mandated restriction.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CAS 959610-24-3. EU: Listed in CosIng as skin conditioning; not restricted under Annexes II, III, V, or VI of Regulation (EC) 1223/2009; no SCCS opinion issued; permitted under Responsible Person CPSR process. US: No FDA ingredient-specific restriction; not subject to OTC monograph; compliant under MoCRA at typical use levels (1-30 ppm). No dedicated CIR report or SCCS opinion exists. Nearest CIR 2018 analogue data shows low acute toxicity (LD50 >2,000 mg/kg), nonirritant, nongenotoxic profile, but read-across to KAKA sequence requires formal justification. Significant safety data gaps.

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

data-gap no-mos no-dermal-absorption no-cir-review no-sccs-opinion read-across-required eye-area-use lipopeptide

Frequently Asked Questions

Is Myristoyl Tetrapeptide-12 safe in cosmetics?

CAS 959610-24-3. EU: Listed in CosIng as skin conditioning; not restricted under Annexes II, III, V, or VI of Regulation (EC) 1223/2009; no SCCS opinion issued; permitted under Responsible Person CPSR process. US: No FDA ingredient-specific restriction; not subject to OTC monograph; compliant under MoCRA at typical use levels (1-30 ppm). No dedicated CIR report or SCCS opinion exists. Nearest CIR 2018 analogue data shows low acute toxicity (LD50 >2,000 mg/kg), nonirritant, nongenotoxic profile, but read-across to KAKA sequence requires formal justification. Significant safety data gaps. The EU classifies Myristoyl Tetrapeptide-12 as "permitted". Safety rating: MODERATE.

Is Myristoyl Tetrapeptide-12 allowed in the EU?

Myristoyl Tetrapeptide-12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Myristoyl Tetrapeptide-12 do in cosmetics?

Myristoyl Tetrapeptide-12 functions as: Skin conditioning, hair growth stimulation (eyelash/eyebrow enhancement, keratinocyte proliferation). It is classified as a cosmetic ingredient in our database. CAS number: 959610-24-3.

What is the Margin of Safety for Myristoyl Tetrapeptide-12?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Myristoyl Tetrapeptide-12 in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Myristoyl Tetrapeptide-12 in your formulation.