Is Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) safe in cosmetics?
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3)
INCI: PALMITOYL PENTAPEPTIDE-4
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) (CAS 214047-00-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, Collagen stimulator. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 214047-00-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, Collagen stimulator
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel concluded safe as used in cosmetics (Final Report September 2024)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3).
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
amino_acid
{"cas_number": "214047-00-4", "ingredient_class": "oligopeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "802", "amino_acid_composition_key": "palmitoyl_KTTKS", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "partially", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "de…
anti_pollution
{"cas_number": "214047-00-4", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal,mature", "acne_safe": "yes", "source": "Matrixyl - anti-aging"}
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.3", "typical_concentration_pct": "0.03", "product_type": "Moisturizer", "function_at_concentration": "Anti-aging", "source": "Supplier TDS"}
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "caution", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "0.5", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "moderate", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "low", "diape…
peptide
{"cas_number": "214047-00-4", "trade_name": "Matrixyl (original)", "peptide_sequence_amino_acids": "Pal-Lys-Thr-Thr-Lys-Ser", "peptide_length_residues": "5", "molecular_weight_daltons": "802.0", "peptide_class": "signal", "mechanism_of_action": "Stimulates fibroblast proliferation and extracellular matrix protein synthesis", "target_protein_or_receptor": "TGF-beta receptor pathway", "biomimetic_of…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "firming", "m…
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3).
Regulatory Lists
Canada
Personal care
Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.0005%. This chemical is not to be used in the eye.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL451881
Frequently Asked Questions
Is Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) allowed in the EU?
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) do in cosmetics?
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) functions as: Skin conditioning agent, Collagen stimulator. It is classified as a cosmetic ingredient in our database. CAS number: 214047-00-4.
Is Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) used outside cosmetics?
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Good
Similar safety
Antioxidant
Matrixyl (Palmitoyl Pentapeptide-4)
Good
Chemical family
Peptide anti-aging active
PALAU WHITE CLAY
Good
Browse nearby
Humectant, Skin Conditioning
PALAU WHITE CLAY EXTRACT
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Humectant
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