Regulatory Status
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Safety Data
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Expert Verdict
CAS 948884-07-9 (CosIng Ref No. 83131). EU: Listed in CosIng under Regulation 1223/2009 with function Skin Conditioning; not listed in Annexes II, III, IV, V, or VI; no SCCS opinion; no concentration limit imposed. US: No FDA prohibition, restriction, or monograph; not classified GRASE; general cosmetic use only. One published split-face RCT (n=20, 0.003% w/w, 60 days) demonstrated non-irritant classification and statistically significant improvement in fine wrinkles. CIR Expert Panel (2022) assessed skin- and connective tissue-derived peptide class as safe in present practices of use.
Regulatory Flags
Frequently Asked Questions
Is Oligopeptide-20 safe in cosmetics?
CAS 948884-07-9 (CosIng Ref No. 83131). EU: Listed in CosIng under Regulation 1223/2009 with function Skin Conditioning; not listed in Annexes II, III, IV, V, or VI; no SCCS opinion; no concentration limit imposed. US: No FDA prohibition, restriction, or monograph; not classified GRASE; general cosmetic use only. One published split-face RCT (n=20, 0.003% w/w, 60 days) demonstrated non-irritant classification and statistically significant improvement in fine wrinkles. CIR Expert Panel (2022) assessed skin- and connective tissue-derived peptide class as safe in present practices of use. The EU classifies Oligopeptide-20 as "permitted". Safety rating: GOOD.
Is Oligopeptide-20 allowed in the EU?
Oligopeptide-20 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Oligopeptide-20 do in cosmetics?
Oligopeptide-20 functions as: Skin conditioning, anti-aging (somatomedin/IGF mimic; promotes collagen, fibronectin, elastin expression). It is classified as a cosmetic ingredient in our database. CAS number: 948884-07-9.
What is the Margin of Safety for Oligopeptide-20?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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