Is Oligopeptide-20 safe in cosmetics?
Oligopeptide-20 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Oligopeptide-20
INCI: OLIGOPEPTIDE-20
Oligopeptide-20 (CAS 948884-07-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning, anti-aging (somatomedin/IGF mimic; promotes collagen,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 948884-07-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, anti-aging (somatomedin/IGF mimic; promotes collagen, fibronectin, elastin expression)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
InChIKey
NZGHUDGEFVXNSR-KILGZPTDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA-specific restriction, prohibition, or monograph applies to Oligopeptide-20. Not classified as GRASE. CIR Expert Panel assessed the broader skin- and connective tissue-derived proteins and peptides class in 2022 and concluded the class is safe in present practices of use. No ingredient-specific CIR assessment exists. General cosmetic ingredient status under FDA jurisdiction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Oligopeptide-20.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Oligopeptide-20.
Regulatory Flags
peptide
high-molecular-weight
skin-conditioning
anti-aging
no-sccs-opinion
thin-safety-dossier
cir-class-assessed
no-mos-calculated
no-systemic-absorption-expected
collagen-stimulating
Frequently Asked Questions
Is Oligopeptide-20 allowed in the EU?
Oligopeptide-20 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Oligopeptide-20 do in cosmetics?
Oligopeptide-20 functions as: Skin conditioning, anti-aging (somatomedin/IGF mimic; promotes collagen, fibronectin, elastin expression). It is classified as a cosmetic ingredient in our database. CAS number: 948884-07-9.
Compliance Tools
Check Oligopeptide-20 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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