Good Cosmetic Ingredient

Palmitoyl Oligopeptide

INCI: PALMITOYL OLIGOPEPTIDE

CAS Number
147732-56-7
Function
Skin conditioning, surfactant-cleansing, anti-aging (ECM protein synthesis stimulation)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA restrictions or GRAS determination applicable. Reported in FDA VCRP 2012 across multiple product categories. CIR Expert Panel published final safety assessment in 2018 concluding safe as used. No specific concentration limits established by CIR or FDA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Palmitoyl Oligopeptide (CAS 147732-56-7) is permitted in the EU without restriction and listed in CosIng. In the US, it is regulated as a cosmetic ingredient with no FDA restrictions; the CIR Expert Panel concluded it safe as used in cosmetics in 2018. Safety is supported by negligible systemic absorption and non-sensitizing profile in human and animal studies. Typical effective concentrations are 3-100 ppm.

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Concern Level: Low

Regulatory Flags

thin-data-package read-across-safety no-sccs-opinion no-formal-mos nomenclature-ambiguity cpsr-justification-required

Frequently Asked Questions

Is Palmitoyl Oligopeptide safe in cosmetics?

Palmitoyl Oligopeptide (CAS 147732-56-7) is permitted in the EU without restriction and listed in CosIng. In the US, it is regulated as a cosmetic ingredient with no FDA restrictions; the CIR Expert Panel concluded it safe as used in cosmetics in 2018. Safety is supported by negligible systemic absorption and non-sensitizing profile in human and animal studies. Typical effective concentrations are 3-100 ppm. The EU classifies Palmitoyl Oligopeptide as "permitted". Safety rating: GOOD.

Is Palmitoyl Oligopeptide allowed in the EU?

Palmitoyl Oligopeptide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Palmitoyl Oligopeptide do in cosmetics?

Palmitoyl Oligopeptide functions as: Skin conditioning, surfactant-cleansing, anti-aging (ECM protein synthesis stimulation). It is classified as a cosmetic ingredient in our database. CAS number: 147732-56-7.

What is the Margin of Safety for Palmitoyl Oligopeptide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Palmitoyl Oligopeptide compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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Oligopeptide-34
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Tripeptide-32
Moderate
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