Good Cosmetic Ingredient

Palmitoyl Tripeptide-28

INCI: PALMITOYL TRIPEPTIDE-28

CAS Number
Not assigned
Function
Skin conditioning agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA: no ingredient-specific restrictions; appears in VCRP data confirming US commercial use. CIR: covered under broad palmitoyl oligopeptides group review (2012/2013); no individual final safety conclusion for Palmitoyl Tripeptide-28. MoCRA compliance requires general safety substantiation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Not listed in EU Annex II/III/IV/V/VI; permitted under Regulation (EC) No 1223/2009 with safety burden on Responsible Person. FDA: no ingredient-specific restrictions; present in VCRP voluntary registrations; subject to MoCRA general product listing. CIR: included in group review of palmitoyl oligopeptides (2012 SLR, 2013 panel); no individual safety conclusion issued. High molecular weight lipopeptide with expected low percutaneous penetration and metabolism to endogenous amino acids and palmitic acid.

⚠️
Concern Level: Low

Regulatory Flags

data-poor no-cas-confirmed no-sccs-opinion no-individual-mos no-individual-sensitization-data no-individual-absorption-data read-across-required supplier-dossier-needed tgf-beta-mimetic ecm-modulator

Frequently Asked Questions

Is Palmitoyl Tripeptide-28 safe in cosmetics?

Not listed in EU Annex II/III/IV/V/VI; permitted under Regulation (EC) No 1223/2009 with safety burden on Responsible Person. FDA: no ingredient-specific restrictions; present in VCRP voluntary registrations; subject to MoCRA general product listing. CIR: included in group review of palmitoyl oligopeptides (2012 SLR, 2013 panel); no individual safety conclusion issued. High molecular weight lipopeptide with expected low percutaneous penetration and metabolism to endogenous amino acids and palmitic acid. The EU classifies Palmitoyl Tripeptide-28 as "permitted". Safety rating: GOOD.

Is Palmitoyl Tripeptide-28 allowed in the EU?

Palmitoyl Tripeptide-28 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Palmitoyl Tripeptide-28 do in cosmetics?

Palmitoyl Tripeptide-28 functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Palmitoyl Tripeptide-28?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Palmitoyl Tripeptide-28 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3)
Good
Dipeptide-4
Good
SH-Oligopeptide-2
Moderate
Acetyl Dipeptide-3 Aminohexanoate
Good
Hexapeptide-2
Moderate
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