Regulatory Status
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Safety Data
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Expert Verdict
Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine, Lubrizol Life Science) is a proprietary synthetic peptide functioning as a skin conditioning agent via stimulation of human beta-defensins hBD-2 and hBD-3, supporting innate antimicrobial skin defense. Not listed in EU Annex II, III, IV, V, or VI — permitted under general provisions of Regulation (EC) 1223/2009. No SCCS opinion issued. No CIR review completed. No FDA restrictions; reported under MoCRA as a cosmetic ingredient. Very low use levels (0.005-0.05%) and peptide hydrolysis read-across are the primary safety arguments available. Formulators must request full toxicology package from supplier. Add below 40°C at final manufacturing stage.
Regulatory Flags
Frequently Asked Questions
Is Acetyl Dipeptide-3 Aminohexanoate safe in cosmetics?
Acetyl Dipeptide-3 Aminohexanoate (Bodyfensine, Lubrizol Life Science) is a proprietary synthetic peptide functioning as a skin conditioning agent via stimulation of human beta-defensins hBD-2 and hBD-3, supporting innate antimicrobial skin defense. Not listed in EU Annex II, III, IV, V, or VI — permitted under general provisions of Regulation (EC) 1223/2009. No SCCS opinion issued. No CIR review completed. No FDA restrictions; reported under MoCRA as a cosmetic ingredient. Very low use levels (0.005-0.05%) and peptide hydrolysis read-across are the primary safety arguments available. Formulators must request full toxicology package from supplier. Add below 40°C at final manufacturing stage. The EU classifies Acetyl Dipeptide-3 Aminohexanoate as "permitted". Safety rating: GOOD.
Is Acetyl Dipeptide-3 Aminohexanoate allowed in the EU?
Acetyl Dipeptide-3 Aminohexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Dipeptide-3 Aminohexanoate do in cosmetics?
Acetyl Dipeptide-3 Aminohexanoate functions as: Skin conditioning agent, Antimicrobial defense stimulator. It is classified as a cosmetic ingredient in our database. CAS number: 1265905-30-3.
What is the Margin of Safety for Acetyl Dipeptide-3 Aminohexanoate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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