N-Methoxyethyl-p-Phenylenediamine HCl

INCI: N-METHOXYETHYL-P-PHENYLENEDIAMINE HCL

CAS Number
66592-87-8 (HCl salt)
Function
Oxidative hair dye (coupler/primary intermediate)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. 2.0%
🇺🇸 US Status permitted
US Notes Permitted under coal tar hair dye exemption (21 USC §361(a)); must carry caution statement and patch-test directions per 21 CFR 740.2

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mandatory 48-hour patch test warning. Potential cross-sensitization with other PPD derivatives. Methoxyethyl moiety may generate formaldehyde upon metabolic cleavage—evaluate case-by-case.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is N-Methoxyethyl-p-Phenylenediamine HCl safe in cosmetics?

Mandatory 48-hour patch test warning. Potential cross-sensitization with other PPD derivatives. Methoxyethyl moiety may generate formaldehyde upon metabolic cleavage—evaluate case-by-case. The EU classifies N-Methoxyethyl-p-Phenylenediamine HCl as "restricted". Safety rating: MODERATE.

Is N-Methoxyethyl-p-Phenylenediamine HCl allowed in the EU?

N-Methoxyethyl-p-Phenylenediamine HCl EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does N-Methoxyethyl-p-Phenylenediamine HCl do in cosmetics?

N-Methoxyethyl-p-Phenylenediamine HCl functions as: Oxidative hair dye (coupler/primary intermediate). It is classified as a cosmetic ingredient in our database. CAS number: 66592-87-8 (HCl salt).

What is the Margin of Safety for N-Methoxyethyl-p-Phenylenediamine HCl?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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