Moderate Cosmetic Ingredient

N-Methyl-3-Nitro-p-Phenylenediamine

INCI: N-METHYL-3-NITRO-P-PHENYLENEDIAMINE

CAS Number
2973-21-9
Function
Semi-permanent (direct) hair dye
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted under coal tar hair dye exemption (21 USC §361(a)); caution statement required per 21 CFR 740.2

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Aromatic nitro group raises genotoxicity and mutagenicity concerns; SCCS has reviewed and imposed strict concentration limits. Reduction of the nitro group in vivo can generate reactive intermediates. Mandatory warning label required.

⚠️
Concern Level: High

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is N-Methyl-3-Nitro-p-Phenylenediamine safe in cosmetics?

Aromatic nitro group raises genotoxicity and mutagenicity concerns; SCCS has reviewed and imposed strict concentration limits. Reduction of the nitro group in vivo can generate reactive intermediates. Mandatory warning label required. The EU classifies N-Methyl-3-Nitro-p-Phenylenediamine as "restricted". Safety rating: MODERATE.

Is N-Methyl-3-Nitro-p-Phenylenediamine allowed in the EU?

N-Methyl-3-Nitro-p-Phenylenediamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does N-Methyl-3-Nitro-p-Phenylenediamine do in cosmetics?

N-Methyl-3-Nitro-p-Phenylenediamine functions as: Semi-permanent (direct) hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 2973-21-9.

What is the Margin of Safety for N-Methyl-3-Nitro-p-Phenylenediamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check N-Methyl-3-Nitro-p-Phenylenediamine compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

2,6-Dihydroxyethylaminotoluene
Good
HC Blue No. 15
Moderate
Basic Red 2
Poor
Pigment Green 7
Good
2-Methoxymethyl-P-Phenylenediamine Sulfate
Good
Browse all 30,000+ ingredients →
📱

Is N-Methyl-3-Nitro-p-Phenylenediamine in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for N-Methyl-3-Nitro-p-Phenylenediamine in your formulation.

Ingredient Decoder MoS Calculator