Is Glucolactone safe in cosmetics?
Glucolactone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Glucolactone
INCI: GLUCONOLACTONE
Glucolactone (CAS 90-80-2 (same as Gluconolactone)) is a cosmetic cosmetic ingredient functioning as Chelating agent, skin conditioning (PHA), antiacne agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 90-80-2 (same as Gluconolactone) →
Function
Chelating agent, skin conditioning (PHA), antiacne agent
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR concluded safe in present practices of use and concentration (Sept 2022); FDA GRAS as food ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glucolactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Glucolactone, relevant to systemic exposure and MoS calculations.
Absorption %
2-5%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
178.1 Da
Log P
-2.1
Systemic Absorption
minimal
Topical Bioavailability
1-3%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Dermatol Surg 2004
Editorial summary
Preliminary editorial summary for Glucolactone — not a computed safety verdict. See the sourced toxicological data above.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Glucolactone by CAS number or substance name.
Studies
3
Lowest NOAEL
560 mg/kg bw/day
Highest NOAEL
695 mg/kg bw/day
ECHA
Frequently Asked Questions
Is Glucolactone allowed in the EU?
Glucolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucolactone do in cosmetics?
Glucolactone functions as: Chelating agent, skin conditioning (PHA), antiacne agent. It is classified as a cosmetic ingredient in our database. CAS number: 90-80-2 (same as Gluconolactone).
Compliance Tools
Check Glucolactone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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