Excellent Cosmetic Ingredient Dermal Penetration

Glucolactone

INCI: GLUCONOLACTONE

CAS Number
90-80-2 (same as Gluconolactone)
Function
Chelating agent, skin conditioning (PHA), antiacne agent
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR concluded safe in present practices of use and concentration (Sept 2022); FDA GRAS as food ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Glucolactone, relevant to systemic exposure and MoS calculations.

Absorption %
2-5%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
178.1 Da
Log P
-2.1
Systemic Absorption
minimal
Topical Bioavailability
1-3%
Safety Margin Factor
minimal
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Dermatol Surg 2004

Expert Verdict

At high concentrations (>10%), may increase photosensitivity like other PHAs; recommend sunscreen pairing. Hydrolyzes to gluconic acid in aqueous systems.

โš ๏ธ
Concern Level: Low

Frequently Asked Questions

Is Glucolactone safe in cosmetics?

At high concentrations (>10%), may increase photosensitivity like other PHAs; recommend sunscreen pairing. Hydrolyzes to gluconic acid in aqueous systems. The EU classifies Glucolactone as "permitted". Safety rating: EXCELLENT.

Is Glucolactone allowed in the EU?

Glucolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glucolactone do in cosmetics?

Glucolactone functions as: Chelating agent, skin conditioning (PHA), antiacne agent. It is classified as a cosmetic ingredient in our database. CAS number: 90-80-2 (same as Gluconolactone).

What is the Margin of Safety for Glucolactone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Glucolactone in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Glucolactone in your formulation.