Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Phenethyl Butyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | other | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 other | oral | rat | oral | REACH |
Expert Verdict
Limited direct toxicological studies; safety assessment relies on structural class read-across and RIFM framework
Regulatory Flags
Frequently Asked Questions
Is Phenethyl Butyrate safe in cosmetics?
Limited direct toxicological studies; safety assessment relies on structural class read-across and RIFM framework The EU classifies Phenethyl Butyrate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Phenethyl Butyrate allowed in the EU?
Phenethyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Butyrate do in cosmetics?
Phenethyl Butyrate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-52-6.
What is the Margin of Safety for Phenethyl Butyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenethyl Butyrate?
The NOAEL (No Observed Adverse Effect Level) for Phenethyl Butyrate is 1000 mg/kg bw/day based on a oral study via other route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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