Phenylalanine

INCI: PHENYLALANINE

CAS Number
63-91-2 (L-Phenylalanine)
Function
Skin conditioning, anti-static
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted; essential amino acid, GRAS status

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Minimal concerns. The CIR has reviewed amino acid alkyl amides (derivatives) and found them safe. Individuals with phenylketonuria (PKU) have systemic sensitivity to phenylalanine, but topical cosmetic exposure is not clinically significant.

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Concern Level: Low

Frequently Asked Questions

Is Phenylalanine safe in cosmetics?

Minimal concerns. The CIR has reviewed amino acid alkyl amides (derivatives) and found them safe. Individuals with phenylketonuria (PKU) have systemic sensitivity to phenylalanine, but topical cosmetic exposure is not clinically significant. The EU classifies Phenylalanine as "permitted". Safety rating: EXCELLENT.

Is Phenylalanine allowed in the EU?

Phenylalanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phenylalanine do in cosmetics?

Phenylalanine functions as: Skin conditioning, anti-static. It is classified as a cosmetic ingredient in our database. CAS number: 63-91-2 (L-Phenylalanine).

What is the Margin of Safety for Phenylalanine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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