CAS Number
Ambiguous — if p-Nitroaniline (4-Nitroaniline): 100-01-6
Function
Hair dye intermediate (historically)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not approved as a color additive by FDA; not GRAS for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

p-Nitroaniline is banned in EU cosmetics, classified as toxic with suspected carcinogenic potential and methemoglobinemia risk; if INCI refers to a different compound, obtain full chemical identity and CAS from supplier immediately.

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Concern Level: High

Frequently Asked Questions

Is PNA safe in cosmetics?

p-Nitroaniline is banned in EU cosmetics, classified as toxic with suspected carcinogenic potential and methemoglobinemia risk; if INCI refers to a different compound, obtain full chemical identity and CAS from supplier immediately. The EU classifies PNA as "prohibited". Safety rating: POOR.

Is PNA allowed in the EU?

PNA EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does PNA do in cosmetics?

PNA functions as: Hair dye intermediate (historically). It is classified as a cosmetic ingredient in our database. CAS number: Ambiguous — if p-Nitroaniline (4-Nitroaniline): 100-01-6.

What is the Margin of Safety for PNA?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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