Good Cosmetic Ingredient Dermal Penetration

Potassium Azeloyl Diglycinate

INCI: POTASSIUM AZELOYL DIGLYCINATE

CAS Number
477773-67-4
Function
Skin brightening, anti-inflammatory, sebum normalizing, skin conditioning, anti-acne
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Parent compound azelaic acid (15-20%) is prescription drug. PAD is unregulated as cosmetic ingredient.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Potassium Azeloyl Diglycinate, relevant to systemic exposure and MoS calculations.

Absorption %
4-8%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
360.4 Da
Log P
-2.1
Systemic Absorption
minimal
Topical Bioavailability
2-6%
Safety Margin Factor
low
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Cosmetic Science

Expert Verdict

Well-tolerated water-soluble azelaic acid derivative with zero adverse events in clinical trial at 5%, but lacks formal CIR or SCCS assessment.

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Concern Level: Low

Frequently Asked Questions

Is Potassium Azeloyl Diglycinate safe in cosmetics?

Well-tolerated water-soluble azelaic acid derivative with zero adverse events in clinical trial at 5%, but lacks formal CIR or SCCS assessment. The EU classifies Potassium Azeloyl Diglycinate as "permitted". Safety rating: GOOD.

Is Potassium Azeloyl Diglycinate allowed in the EU?

Potassium Azeloyl Diglycinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Azeloyl Diglycinate do in cosmetics?

Potassium Azeloyl Diglycinate functions as: Skin brightening, anti-inflammatory, sebum normalizing, skin conditioning, anti-acne. It is classified as a cosmetic ingredient in our database. CAS number: 477773-67-4.

What is the Margin of Safety for Potassium Azeloyl Diglycinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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