Good Active Ingredient Dermal Penetration

Azeloglicina (PAD)

INCI: POTASSIUM AZELOYL DIGLYCINATE

CAS Number
477773-67-4
Function
anti-aging
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 12.7%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR Expert Panel concluded dicarboxylic acids (including azelaic acid salts and esters) are safe in present practices of use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Azeloglicina (PAD), relevant to systemic exposure and MoS calculations.

Absorption %
4-8%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
360.4 Da
Log P
-2.1
Systemic Absorption
minimal
Topical Bioavailability
2-6%
Safety Margin Factor
low
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Cosmetic Science

Expert Verdict

Potassium Azeloyl Diglycinate is generally considered safe for use as an anti-aging ingredient.

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Concern Level: Low

Frequently Asked Questions

Is Azeloglicina (PAD) safe in cosmetics?

Potassium Azeloyl Diglycinate is generally considered safe for use as an anti-aging ingredient. The EU classifies Azeloglicina (PAD) as "permitted". Safety rating: GOOD.

Is Azeloglicina (PAD) allowed in the EU?

Azeloglicina (PAD) EU regulatory status: permitted. Maximum allowed concentration: 12.7%. This is based on EU Regulation 1223/2009 and its amendments.

What does Azeloglicina (PAD) do in cosmetics?

Azeloglicina (PAD) functions as: anti-aging. It is classified as a Active Ingredient in our database. CAS number: 477773-67-4.

What is the Margin of Safety for Azeloglicina (PAD)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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