Moderate Cosmetic Ingredient GHS Classified

Propionaldehyde

INCI: PROPIONALDEHYDE (PROPANAL)

CAS Number
123-38-6
Function
Fragrance ingredient; flavouring substance; used in perfume and cosmetic manufacturing
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted; GRAS for flavoring; allowed in cosmetics under fragrance provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The vapour is irritating to the eyes and respiratory tract. The substance is severely irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Highly flammable (H225); causes serious eye damage (H318); skin irritant (H315); positive in some in vitro mutagenicity assays — DNA damage noted . Requires careful concentration limits in formulation

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Concern Level: High

Regulatory Flags

fragrance-component endocrine_disruptor ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Propionaldehyde safe in cosmetics?

Highly flammable (H225); causes serious eye damage (H318); skin irritant (H315); positive in some in vitro mutagenicity assays — DNA damage noted . Requires careful concentration limits in formulation The EU classifies Propionaldehyde as "prohibited". Safety rating: MODERATE.

Is Propionaldehyde allowed in the EU?

Propionaldehyde EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Propionaldehyde do in cosmetics?

Propionaldehyde functions as: Fragrance ingredient; flavouring substance; used in perfume and cosmetic manufacturing. It is classified as a cosmetic ingredient in our database. CAS number: 123-38-6.

What is the Margin of Safety for Propionaldehyde?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Propionaldehyde compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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